Ayahuasca, San Pedro and other Plant Medicine is generally a very safe substance to drink. There are some medical conditions (e.g. some stomach, heart, liver, kidney, colon or mental health problems, etc.) where drinking ayahuasca could be potentially harmful. Please check with your doctor and take their advice about participation. Specific conditions with which one should definitely NOT drink ayahuasca are heart problems, kidney disorders, high blood pressure, schizophrenia, bipolar disorder, and any history of psychosis or psychotic breaks. Please take this seriously as the potential consequences are an extended trip to a psychiatric hospital or death. Also, any hallucinogen can trigger underlying emotional problems or exacerbate mental conditions. Anyone with a family history of poor psychological health, especially schizophrenic-type disorders should be especially cautious about taking ayahuasca. Ayahuasca ( Banisteriopsis caapi ) contains monoamine oxidase inhibitors (MAOIs) in the form of harmine and harmaline. Medications in the class of selective serotonin reuptake inhibitors (SSRIs) and serotonin- norepinephrine reuptake Inhibitors (SNRIs), which includes most antidepressants, are dangerous to take with MAOIs and need to be stopped 1-4 weeks before drinking ayahuasca, depending on the shelf life of the specific medicine being taken. This is very important, as mixing these two types of substances can lead to serotonin syndrome which can be fatal.